Constant Freezing and "Not Responding"
There have been numerous posts about freezing. I have tried all of the suggested fixes - deleting and disabling Add-Ons, reloading Thunderbird, etc. etc. But it continues to constantly freeze and says "Not Responding" - sometimes taking 20 to 30 seconds to unfreeze - other times I have to wait several minutes for it to unfreeze. I have used TB for many years, but it is now becoming unusable.
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I have tried all of the suggested fixes - deleting and disabling Add-Ons, reloading Thunderbird, etc. etc.
That is just going to lead to more replication of suggestions because it does not actually say what you have tried.
My personal best suggestion is to rebuild the global database https://support.mozilla.org/en-US/kb/rebuilding-global-database.
Then move on to https://wiki.mozilla.org/Thunderbird:Testing:Memory_Usage_Problems
Despite what it says on the web site. Thunderbird needs at least 8Gb of ram and free disk space on the profile drive around twice the size of the profile. Generally this is some gigbytes free on both the system drive and the profile drive if it is not the default.